Complex Relationship between Mismatch Repair Proteins and MBD4 during Immunoglobulin Class Switch Recombination
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چکیده
منابع مشابه
Complex Relationship between Mismatch Repair Proteins and MBD4 during Immunoglobulin Class Switch Recombination
Mismatch repair (MMR) safeguards against genomic instability and is required for efficient Ig class switch recombination (CSR). Methyl CpG binding domain protein 4 (MBD4) binds to MutL homologue 1 (MLH1) and controls the post-transcriptional level of several MMR proteins, including MutS homologue 2 (MSH2). We show that in WT B cells activated for CSR, MBD4 is induced and interacts with MMR prot...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0078370